CNValidator: validating somatic copy-number inference
نویسندگان
چکیده
منابع مشابه
Modulating somatic DNA copy number through maternal RNA.
M aintaining genome stability is a fundamental aspect of life. It is critical for proper gene expression and transmission. However, the genome is also highly dynamic, with alterations occurring in various forms during cell growth, division, and/or differentiation. One important aspect of these alterations is in gene dosage. For instance, gene duplications or amplifications have been known to oc...
متن کاملDetection of germline and somatic copy number variations in cattle.
As a complement to the Bovine HapMap Consortium project, we initiated a systematic study of the copy numbervariation (CNV) within the same cattle population using array comparative genomic hybridization (array CGH). Oligonucleotide CGH arrays were designed and fabricated to cover all chromosomes with an average interval of 6 kb using the latest bovine genome assembly. In the initial screening, ...
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A powerful way to discover key genes playing causal roles in oncogenesis is to identify genomic regions that undergo frequent alteration in human cancers. Here, we report high-resolution analyses of somatic copy-number alterations (SCNAs) from 3131 cancer specimens, belonging largely to 26 histological types. We identify 158 regions of focal SCNA that are altered at significant frequency across...
متن کاملSomatic copy-neutral loss of heterozygosity and copy number abnormalities in Malaysian sporadic colorectal carcinoma patients.
Colorectal cancer is one of the most common cancers in many countries, including Malaysia. The accumulation of genomic alterations is an important feature of colorectal carcinogenesis. A better understanding of the molecular events underlying the stages of colorectal carcinogenesis might be helpful in the detection and management of the disease. We used a commercially available single-nucl...
متن کاملUse of Low Copy Number (lcn) Dna in Forensic Inference
Development of a low copy number DNA profiling method has allowed the detection of very low levels of DNA. However, issues concerning the transfer and persistence of LCN DNA have required further research to be carried out; this has included studies of individuals’ tendency to deposit and transfer DNA onto surfaces they have touched. Additionally, the effect on DNA of some of the enhancement tr...
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ژورنال
عنوان ژورنال: Bioinformatics
سال: 2018
ISSN: 1367-4803,1460-2059
DOI: 10.1093/bioinformatics/bty1022